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| Last update: 2022/07/12 |
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Supervisor: Dr. Mahnaz Eskandari
Phone: +98 -21 64542362
Email: eskandarim
aut.ac.irAddress: Introduction: Marashi Alley, Saeed St., Tehran, Iran 1591634311
Welcome to the website of Biophotonics Laboratory. This laboratory is in the Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic). Our goal in this laboratory is to develop imaging methods with the help of electromagnetic waves to diagnose and treat diseases and regenerate damaged tissues. The tissues and material that we mainly research on are:
- Cancerous masses, especially breast and skin cancer
- The retina consisting of the cellular layers of the retina, its neural network, and its capillary network
- Injectable hydrogels that can carry drug-containing nanoparticles, energy storage, genes, or cells
- Intelligent scaffolds sensitive to electromagnetic fields and pH
The main areas of our research in our lab are:
1. Quantitative and qualitative study of the effect of electromagnetic waves on cell behavior
These waves are used independently and combined with various nanoparticles and therapeutic drugs to achieve new treatment strategies for diseases such as cancer. In these studies, we seek to have the highest rate of undesirable cell removal with the fewest side effects (including minimal death of healthy cells). A significant range of wavelengths and radiation powers are used to achieve this goal. In this laboratory, we are also researching how to create cancerous tissues using bioprinting methods so that we can study treatment strategies with their help. This study includes items such as:
1.1. Study the effect of electromagnetic wave variables on the molecular biology of cells
1.2. Study of the effect of electromagnetic waves on the effectiveness of chemotherapy and gene therapy
1.3. Design and manufacture of microfluidic systems to produce drug or gene-carrying microgels
1.4. Design and construction of appropriate micro-reactors that simulate cellular microenvironments so that therapeutic strategies can be studied in them
1.5. Development of photonic methods for early detection of cancer using biomarkers
1.2. Study of the effect of electromagnetic waves on the effectiveness of chemotherapy and gene therapy
1.3. Design and manufacture of microfluidic systems to produce drug or gene-carrying microgels
1.4. Design and construction of appropriate micro-reactors that simulate cellular microenvironments so that therapeutic strategies can be studied in them
1.5. Development of photonic methods for early detection of cancer using biomarkers
2. Reconstruction and treatment of retinal tissue
These studies include the following subsets:
2.1. Development and construction of a suitable scaffold for simulating a suitable microenvironment for retinal cells, endothelial cells, and nerve cells
2.2. Research and development in drug carriers for ophthalmic drugs that provide the longest release time of the drug, have a significant effect on the posterior part of the eye, cause minor side effects, and have the most excellent effect.
2.3. Design and fabrication of microfluidic systems to produce microgel carrying drugs or genes into the eyeball and drugs into the cornea
2.4. Design and construction of suitable micro-reactors that can simulate the microenvironment inside the eyeball, especially according to the amount of light entering the eyeball. In these micro-reactors, the cellular behavior of different types of retinal cells at different stages of differentiation, growth, and proliferation are studied.
2.5. Design and fabricate appropriate micro-reactors that can simulate the microenvironment inside the eyeball to study the cellular behavior of different retinal cell lines, the effectiveness of drugs, and treatment methods.
2.6. Development of photonic methods for early detection of vision problems caused by retinal tissue
2.2. Research and development in drug carriers for ophthalmic drugs that provide the longest release time of the drug, have a significant effect on the posterior part of the eye, cause minor side effects, and have the most excellent effect.
2.3. Design and fabrication of microfluidic systems to produce microgel carrying drugs or genes into the eyeball and drugs into the cornea
2.4. Design and construction of suitable micro-reactors that can simulate the microenvironment inside the eyeball, especially according to the amount of light entering the eyeball. In these micro-reactors, the cellular behavior of different types of retinal cells at different stages of differentiation, growth, and proliferation are studied.
2.5. Design and fabricate appropriate micro-reactors that can simulate the microenvironment inside the eyeball to study the cellular behavior of different retinal cell lines, the effectiveness of drugs, and treatment methods.
2.6. Development of photonic methods for early detection of vision problems caused by retinal tissue
3. Injectable hydrogels
These hydrogels have various applications in biomedical engineering. For example, they are used in multiple types of medical imaging to observe tissue density and diagnosis. They have also been used to inject drugs, genes, or cells into target tissues. Another application of these hydrogels is in bioprinters as a bio-printer. The tissue from these printers can be used to study drugs and treatments instead of living animals. These hydrogels are best able to carry drugs, genes, or cells. Studies in this section include:
3.1. Study the effect of electromagnetic waves on the average life, degradation, and by-products of degradation of hydrogels
3.2. Design and fabrication of photomicroreometer systems to study the viscoelastic properties of injectable hydrogels
3.2. Design and fabrication of photomicroreometer systems to study the viscoelastic properties of injectable hydrogels
Attachments on the lab site:
1. Application to join Dr. Mahnaz Eskandari's research group (undergraduate, graduate, doctoral and postdoctoral project)
2. Application form for 808 nm laser
3. Weekly schedule of laboratory experts
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If you are interested in collaborating with this research lab, you can contact Dr. Mahnaz Eskandari (eskandari.edu
gmail.com or eskandarimaut.ac.ir).
gmail.com or eskandarimaut.ac.ir).
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